Thanks to Microsoft wanting to add more security and features to Windows Vista with SP1 some gamers have to suffer with the random issues that come along with it. I recently built a brand new computer (2days ago) and had an issue running one of my Favorite online games City of Heros/City of Villains with Ventrilo.
Issue: For some reason Ventrilo was not picking up my PTT key while in game but if I minimized the game it would work just fine..
Fix: Right click the Ventrilo shortcut and select run as Administrator and then click allow. This should solve the issue for many games with this issue.
Why: City of Heros runs as Administrator due to the continuous access to the Program Files folder. A work around for this is to install City of Heros to C:\ rather then C:\Program Files\ or to a non OS harddrive but that work-around didnt work for me some reason. So because Vista has such an annoying security feature called UAC. When City of Heros or other random games (that run as Administrator) are the active window aka your playing the game, UAC blocks other programs from hooking your mouse and keyboard events. So running Ventrilo as Administrator allows it to hook events when your in game because its running as the same user. Oddly enough it still works as normal when your not in game as well (example: Surfing the internet)
